Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramming of the human tRNA epitranscriptome

Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramming of the human tRNA epitranscriptome

<jats:p>Cells respond to environmental stress by regulating gene expression at the level of both transcription and translation. The ∼50 modified ribonucleotides of the human epitranscriptome contribute to the latter, with mounting evidence that dynamic regulation of transfer RNA (tRNA) wobble...

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Bibliographic Details
Main Authors: Huber, Sabrina M, Begley, Ulrike, Sarkar, Anwesha, Gasperi, William, Davis, Evan T, Surampudi, Vasudha, Lee, May, Melendez, J Andres, Dedon, Peter C, Begley, Thomas J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2023
Online Access:https://hdl.handle.net/1721.1/147796

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https://hdl.handle.net/1721.1/147796

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