Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

<jats:p> Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest immunogenicity. One approach that has been explored to enhance peptide vaccine potency is covalent conjugation of antigens with cell-penetrating peptides (CPPs), linear cationic and amp...

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Bibliographic Details
Main Authors: Backlund, Coralie M, Holden, Rebecca L, Moynihan, Kelly D, Garafola, Daniel, Farquhar, Charlotte, Mehta, Naveen K, Maiorino, Laura, Pham, Sydney, Iorgulescu, J Bryan, Reardon, David A, Wu, Catherine J, Pentelute, Bradley L, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2023
Online Access:https://hdl.handle.net/1721.1/147836

Internet

https://hdl.handle.net/1721.1/147836

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