Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity

Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity

<jats:p>To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization strategies are needed that elicit protection at mucosal portals of pathogen entry. Immunization directly through airway surfaces is effective in driving mucosal immunity, but poor vaccine uptake across the...

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Bibliographic Details
Main Authors: Hartwell, Brittany L, Melo, Mariane B, Xiao, Peng, Lemnios, Ashley A, Li, Na, Chang, Jason YH, Yu, Jingyou, Gebre, Makda S, Chang, Aiquan, Maiorino, Laura, Carter, Crystal, Moyer, Tyson J, Dalvie, Neil C, Rodriguez-Aponte, Sergio A, Rodrigues, Kristen A, Silva, Murillo, Suh, Heikyung, Adams, Josetta, Fontenot, Jane, Love, J Christopher, Barouch, Dan H, Villinger, Francois, Ruprecht, Ruth M, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023
Online Access:https://hdl.handle.net/1721.1/147841

Internet

https://hdl.handle.net/1721.1/147841

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