STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity

STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity

<jats:title>Abstract</jats:title><jats:p>Activation of the innate immune STimulator of INterferon Genes (STING) pathway potentiates antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We conjugated STING-activating cyclic dinucleotides (CDNs) to...

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Bibliographic Details
Main Authors: Dane, Eric L, Belessiotis-Richards, Alexis, Backlund, Coralie, Wang, Jianing, Hidaka, Kousuke, Milling, Lauren E, Bhagchandani, Sachin, Melo, Mariane B, Wu, Shengwei, Li, Na, Donahue, Nathan, Ni, Kaiyuan, Ma, Leyuan, Okaniwa, Masanori, Stevens, Molly M, Alexander-Katz, Alfredo, Irvine, Darrell J
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/147842

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