Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs

Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs

CRISPR-based diagnostics enable specific sensing of DNA and RNA biomarkers associated with human diseases. This is achieved through the binding of guide RNAs to a complementary sequence that activates Cas enzymes to cleave reporter molecules. Currently, most CRISPR-based diagnostics rely on target p...

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Bibliographic Details
Main Authors: Broto, Marta, Kaminski, Michael M, Adrianus, Christopher, Kim, Nayoung, Greensmith, Robert, Dissanayake-Perera, Schan, Schubert, Alexander J, Tan, Xiao, Kim, Hyemin, Dighe, Anand S, Collins, James J, Stevens, Molly M
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/147986

Internet

https://hdl.handle.net/1721.1/147986

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