A coarse-grained mechanical model for folding and unfolding of tropoelastin with possible mutations

We propose a simple general framework to predict folding, native states, energy barriers, protein unfolding, as well as mutation induced diseases and other protein structural analyses. The model should not be considered as an alternative to classical approaches (Molecular Dynamics or Monte Carlo) be...

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Bibliographic Details
Main Authors: Florio, Giuseppe, Pugno, Nicola M, Buehler, Markus J, Puglisi, Giuseppe
Other Authors: Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/148566