Discovering design principles of collagen molecular stability using a genetic algorithm, deep learning, and experimental validation

<jats:p> Collagen is the most abundant structural protein in humans, providing crucial mechanical properties, including high strength and toughness, in tissues. Collagen-based biomaterials are, therefore, used for tissue repair and regeneration. Utilizing collagen effectively duri...

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Bibliographic Details
Main Authors: Khare, Eesha, Yu, Chi-Hua, Gonzalez Obeso, Constancio, Milazzo, Mario, Kaplan, David L, Buehler, Markus J
Other Authors: Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2023
Online Access:https://hdl.handle.net/1721.1/148571