Discovering design principles of collagen molecular stability using a genetic algorithm, deep learning, and experimental validation
<jats:p> Collagen is the most abundant structural protein in humans, providing crucial mechanical properties, including high strength and toughness, in tissues. Collagen-based biomaterials are, therefore, used for tissue repair and regeneration. Utilizing collagen effectively duri...
Main Authors: | Khare, Eesha, Yu, Chi-Hua, Gonzalez Obeso, Constancio, Milazzo, Mario, Kaplan, David L, Buehler, Markus J |
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Other Authors: | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
Format: | Article |
Language: | English |
Published: |
Proceedings of the National Academy of Sciences
2023
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Online Access: | https://hdl.handle.net/1721.1/148571 |
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