Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC)

Antiandrogen-Equipped Histone Deacetylase Inhibitors Selectively Inhibit Androgen Receptor (AR) and AR-Splice Variant (AR-SV) in Castration-Resistant Prostate Cancer (CRPC)

Background: Epigenetic modification influences androgen receptor (AR) activation, often resulting in prostate cancer (PCa) development and progression. Silencing histone-modifying enzymes (histone deacetylases-HDACs) either genetically or pharmacologically suppresses PCa proliferation in preclinical...

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Bibliographic Details
Main Authors: Chandrasekaran, Balaji, Tapadar, Subhasish, Wu, Bocheng, Saran, Uttara, Tyagi, Ashish, Johnston, Alexis, Gaul, David A., Oyelere, Adegboyega K., Damodaran, Chendil
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Multidisciplinary Digital Publishing Institute 2023
Online Access:https://hdl.handle.net/1721.1/148815

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https://hdl.handle.net/1721.1/148815

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