Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

<jats:title>Abstract</jats:title><jats:p>Striatal projection neurons (SPNs), which progressively degenerate in human patients with Huntington’s disease (HD), are classified along two axes: the canonical direct-indirect pathway division and the striosome-matrix compartmentation. It...

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Bibliographic Details
Main Authors: Matsushima, Ayano, Pineda, Sergio Sebastian, Crittenden, Jill R, Lee, Hyeseung, Galani, Kyriakitsa, Mantero, Julio, Tombaugh, Geoffrey, Kellis, Manolis, Heiman, Myriam, Graybiel, Ann M
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/148818

Internet

https://hdl.handle.net/1721.1/148818

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