GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

How does chronic activity modulation lead to global remodeling of proteins at synapses and synaptic scaling? Here we report that guanylate kinase-associated protein (GKAP; also known as SAPAP), a scaffolding molecule linking NMDA receptor-PSD-95 to Shank-Homer complexes, acts in these processes. Ove...

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Bibliographic Details
Main Authors: Shin, Seung Min, Zhang, Nanyan, Hansen, Jonathan, Gerges, Nashaat Z, Pak, Daniel TS, Sheng, Morgan, Lee, Sang H
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2023
Online Access:https://hdl.handle.net/1721.1/150027

Internet

https://hdl.handle.net/1721.1/150027

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