Evolution of nutrient sensing in the mTORC1 pathway
The mTORC1 pathway regulates growth and metabolism in response to nutrient availability. In mammals, the mTORC1 pathway monitors the concentration of certain amino acids using dedicated nutrient sensors, which bind directly to their cognate metabolites. Unlike other components of the mTORC1 pathway,...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2023
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| Online Access: | https://hdl.handle.net/1721.1/150126 https://orcid.org/0000-0001-5463-3055 |