Suppression of the Ubiquitin Ligase Function of FBXW7 Accelerates Metastatic Progression of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal common malignancy because it is usually diagnosed at an advanced/metastatic stage. Dysregulation of protein stability and degradation has been associated with uncontrolled proliferation and genomic instability, promoting cancer progression t...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2023
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| Online Access: | https://hdl.handle.net/1721.1/150167 |