The impact of intratumor heterogeneity on anti-tumor immunity

Cancer immunotherapies, notably checkpoint blockade therapy (CBT), have proven efficacy to control cancer growth, with a fraction of patients exhibiting durable responses. However, the majority of patients do not respond to CBT and the molecular determinants of resistance have not been fully charact...

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Bibliographic Details
Main Author: Nguyen, Kim Bich
Other Authors: Spranger, Stefani
Format: Thesis
Published: Massachusetts Institute of Technology 2023
Online Access:https://hdl.handle.net/1721.1/150240
https://orcid.org/0000-0002-2269-6809