Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21) and characterized by a wide range of neurodevelopmental and physical disabilities. Transcriptomic analysis of tissue samples from individuals with DS has revealed that T21 induces a genome-wide transcriptional...

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Bibliographic Details
Main Authors: Meharena, Hiruy S, Marco, Asaf, Dileep, Vishnu, Lockshin, Elana R, Akatsu, Grace Y, Mullahoo, James, Watson, L Ashley, Ko, Tak, Guerin, Lindsey N, Abdurrob, Fatema, Rengarajan, Shruthi, Papanastasiou, Malvina, Jaffe, Jacob D, Tsai, Li-Huei
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/150412

Internet

https://hdl.handle.net/1721.1/150412

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