A transcription factor atlas of directed differentiation

Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular processes and cell states. To comprehensively understand TFs and the programs they control, we created a barcoded library of all annotated human TF splice isoforms (>3,500) and applied it to build a TF Atlas...

Full description

Bibliographic Details
Main Authors: Joung, Julia, Ma, Sai, Tay, Tristan, Geiger-Schuller, Kathryn R, Kirchgatterer, Paul C, Verdine, Vanessa K, Guo, Baolin, Arias-Garcia, Mario A, Allen, William E, Singh, Ankita, Kuksenko, Olena, Abudayyeh, Omar O, Gootenberg, Jonathan S, Fu, Zhanyan, Macrae, Rhiannon K, Buenrostro, Jason D, Regev, Aviv, Zhang, Feng
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Elsevier BV 2023
Online Access:https://hdl.handle.net/1721.1/150445