Feedforward growth rate control mitigates gene activation burden
<jats:title>Abstract</jats:title><jats:p>Heterologous gene activation causes non-physiological burden on cellular resources that cells are unable to adjust to. Here, we introduce a feedforward controller that actuates growth rate upon activation of a gene of interest (GOI) to compe...
Main Authors: | Barajas, Carlos, Huang, Hsin-Ho, Gibson, Jesse, Sandoval, Luis, Del Vecchio, Domitilla |
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Other Authors: | Massachusetts Institute of Technology. Department of Mechanical Engineering |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2023
|
Online Access: | https://hdl.handle.net/1721.1/150903 |
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