Development of Dendritic Polymers as a Modular Drug Delivery Platform for Avascular Tissues

Avascular tissues, such as articular cartilage, meniscus, intervertebral discs, and cornea stroma, pose a number of challenges for disease treatment. Systemic therapies will not reach the target tissue at efficacious levels. Local therapies are rapidly cleared from the tissue due to turnover of biol...

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Bibliographic Details
Main Author: Johnston, Brandon Michael
Other Authors: Hammond, Paula T.
Format: Thesis
Published: Massachusetts Institute of Technology 2023
Online Access:https://hdl.handle.net/1721.1/151302