Interpretations of Machine Learning and Their Application to Therapeutic Design

We introduce a framework for interpreting black-box machine learning (ML) models, discover overinterpretation as a failure mode of deep neural networks, and discuss how ML methods can be applied for therapeutic design, including a pan-variant COVID-19 vaccine. While ML models are widely deployed an...

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Bibliographic Details
Main Author: Carter, Brandon M.
Other Authors: Gifford, David K.
Format: Thesis
Published: Massachusetts Institute of Technology 2023
Online Access:https://hdl.handle.net/1721.1/151487
https://orcid.org/0000-0002-6318-2521