Correlation-based Linking of Epigenomic Regions to Target Genes in Bulk and Single Cell Epigenomic Data

Single-cell sequencing has catalyzed a significant shift in biological modeling and hypothesis generation. In this study, we present advanced algorithms that utilize multiple modalities for peak-gene linking via correlation-based mechanisms. This approach provides a robust framework for bias correct...

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Bibliographic Details
Main Author: James, Benjamin Thomas
Other Authors: Kellis, Manolis
Format: Thesis
Published: Massachusetts Institute of Technology 2023
Online Access:https://hdl.handle.net/1721.1/151538