Affinity Maturation of Peptides to Bind Protein-Protein Interfaces
The use of peptides as inhibitors for protein-protein interactions (PPI) is an attractive strategy for developing therapeutics. Understanding the structure-activity relationships of peptide-based inhibitors is crucial for optimizing their activity. To guide this optimization, combinatorial peptide l...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2023
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| Online Access: | https://hdl.handle.net/1721.1/152135 |