SCA: recovering single-cell heterogeneity through information-based dimensionality reduction

Abstract Dimensionality reduction summarizes the complex transcriptomic landscape of single-cell datasets for downstream analyses. Current approaches favor large cellular populations defined by many genes, at the expense of smaller and more subtly defined populations. Here, we present...

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Bibliographic Details
Main Authors: DeMeo, Benjamin, Berger, Bonnie
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:English
Published: BioMed Central 2023
Online Access:https://hdl.handle.net/1721.1/152252