Changing protein-DNA interactions promote ORC binding site exchange during replication origin licensing
DNA replication is a fundamental process that ensures the faithful duplication of genetic material in all living organisms. In eukaryotic cells, DNA replication proceeds bidirectionally from origins of replication. At the heart of this process is the eukaryotic replicative helicase, Mcm2-7, which le...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2023
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| Online Access: | https://hdl.handle.net/1721.1/153031 |