Engineering minimally immunogenic cargos and delivery modalities for gene therapy

Since the discovery of CRISPR-Cas9 systems, gene therapies have revolutionized the field of molecular biology by introducing functional genes into cells to correct genetic defects or diseases. To date, several gene therapies are pending approval for use in the clinic and have shown promise in the tr...

Full description

Bibliographic Details
Main Author: Raghavan, Rumya S.
Other Authors: Zhang, Feng
Format: Thesis
Published: Massachusetts Institute of Technology 2024
Online Access:https://hdl.handle.net/1721.1/153703