Development of Chemically-Defined Platform Materials for Localized Delivery of RNA Therapeutics
Most nucleic acid therapeutics have been engineered for systemic delivery with accumulation predominantly occurring in the liver. Currently, mRNA and siRNA represent the most clinically advanced nucleic acid modalities which can be used to address underlying under- or over-expression of crucial prot...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/154211 |