Development of Chemically-Defined Platform Materials for Localized Delivery of RNA Therapeutics

Development of Chemically-Defined Platform Materials for Localized Delivery of RNA Therapeutics

Most nucleic acid therapeutics have been engineered for systemic delivery with accumulation predominantly occurring in the liver. Currently, mRNA and siRNA represent the most clinically advanced nucleic acid modalities which can be used to address underlying under- or over-expression of crucial prot...

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Bibliographic Details
Main Author:	Andresen, Jason Lee
Other Authors:	Langer, Robert
Format:	Thesis
Published:	Massachusetts Institute of Technology 2024
Online Access:	https://hdl.handle.net/1721.1/154211

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