Targeting PRMT5 impairs cancer proliferation through splicing but promotes state shifts that enable resistance and disease progression
Epigenetic regulators play key roles in disease and development. Cancers can hijack developmental processes and mechanisms to grow and survive, including re-activating expression of epigenetic regulators normally confined to developing cells. One such regulator is protein arginine methyltransferase...
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/155362 https://orcid.org/0000-0002-6281-2851 |