YAP and TAZ have Functionally Redundant Roles in Uveal Melanoma
Uveal Melanoma (UM) is the primary ocular malignancy in adults. The primary tumor is treatable but 50% of patients develop fatal metastases. Most UM are driven by activating mutations in the heterotrimeric G protein alpha subunits paralogs, GNAQ or GNA11, whose main downstream effectors are MAPK sig...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/155388 |