A Self-Polymerizing Mesh of Nano-Tethers for the Mechanical Constraint of Degraded Intervertebral Discs—A Review of 25 Years of Pre-Clinical and Early Clinical Research

Genipin polymers are self-forming tensile-load-carrying oligomers, derived from the gardenia fruit, that covalently bond to amines on collagen. The potential therapeutic mechanical benefits of a non-discrete in situ forming mesh of genipin oligomers for degraded spinal discs were first conceived in...

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Bibliographic Details
Main Authors: Hedman, Thomas, Rogers, Adam, Beall, Douglas
Format: Article
Published: MDPI AG 2024
Online Access:https://hdl.handle.net/1721.1/155437