Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

Use of Transient Transfection for cGMP Manufacturing of eOD-GT8 60mer, a Self-Assembling Nanoparticle Germline-Targeting HIV-1 Vaccine Candidate

We describe the current Good Manufacturing Practice (cGMP) production and subsequent characterization of eOD-GT8 60mer, a glycosylated self-assembling nanoparticle HIV-1 vaccine candidate and germline targeting priming immunogen. Production was carried out via transient expression in the human embry...

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Bibliographic Details
Main Authors: Sharma, Vaneet K., Menis, Sergey, Brower, Evan T., Sayeed, Eddy, Ackland, Jim, Lombardo, Angela, Cottrell, Christopher A., Torres, Jonathan L., Hassell, Thomas, Ward, Andrew B., Tsvetnitsky, Vadim, Schief, William R.
Other Authors: Ragon Institute of MGH, MIT and Harvard
Format: Article
Published: MDPI AG 2024
Online Access:https://hdl.handle.net/1721.1/155438

Internet

https://hdl.handle.net/1721.1/155438

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