Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response

Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response

Biomedical devices comprise a major component of modern medicine, however immune-mediated fibrosis and rejection can limit their function over time. Here, we describe a humanized mouse model that recapitulates fibrosis following biomaterial implantation. Cellular and cytokine responses to multiple b...

Full description

Bibliographic Details
Main Authors: Doloff, Joshua C, Ma, Minglin, Sadraei, Atieh, Tam, Hok Hei, Farah, Shady, Hollister-Lock, Jennifer, Vegas, Arturo J, Veiseh, Omid, Quiroz, Victor M, Rakoski, Amanda, Aresta-DaSilva, Stephanie, Bader, Andrew R, Griffin, Marissa, Weir, Gordon C, Brehm, Michael A, Shultz, Leonard D, Langer, Robert, Greiner, Dale L, Anderson, Daniel G
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: American Association for the Advancement of Science 2024
Online Access:https://hdl.handle.net/1721.1/156884

Internet

https://hdl.handle.net/1721.1/156884

Similar Items