In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy

In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy

Multiple myeloma (MM), a hematologic malignancy that preferentially colonizes the bone marrow, remains incurable with a survival rate of 3 to 6 mo for those with advanced disease despite great efforts to develop effective therapies. Thus, there is an urgent clinical need for innovative and more effe...

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Bibliographic Details
Main Authors: Guimarães, Pedro PG, Figueroa-Espada, Christian G, Riley, Rachel S, Gong, Ningqiang, Xue, Lulu, Sewastianik, Tomasz, Dennis, Peter S, Loebel, Claudia, Chung, Amanda, Shepherd, Sarah J, Haley, Rebecca M, Hamilton, Alex G, El-Mayta, Rakan, Wang, Karin, Langer, Robert, Anderson, Daniel G, Carrasco, Ruben D, Mitchell, Michael J
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2024
Online Access:https://hdl.handle.net/1721.1/156885

Internet

https://hdl.handle.net/1721.1/156885

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