Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species

One of the key steps in eukaryotic gene expression is pre-mRNA splicing, whereby intronic sequences are excised from immature pre-mRNA transcripts and the remaining exonic sequences are joined together. This process is catalyzed by the spliceosome, a large complex of proteins and RNAs. A variety of...

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Bibliographic Details
Main Author: McCue, Kayla M.
Other Authors: Burge, Christopher B.
Format: Thesis
Published: Massachusetts Institute of Technology 2024
Online Access:https://hdl.handle.net/1721.1/156986