Sequence-Dependent & -Independent Effects of Intron-Mediated Enhancement (IME)
Introns are ubiquitous features of eukaryotic genes, and their precise removal from pre-mRNA transcripts by the spliceosome is an essential step in gene expression. Genomic deletion of an intron from a gene tends to reduce its expression, and addition of an intron tends to increase it. This phenomen...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Published: |
Massachusetts Institute of Technology
2024
|
| Online Access: | https://hdl.handle.net/1721.1/157229 https://orcid.org/0000-0002-8992-7608 |