Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency
Inosine is a nucleoside formed by deamination of adenosine by adenosine deaminases acting on RNA (ADAR). ADAR editing activity is known to play a key role in modulating the host cell’s immune response to RNA. Here, we specifically study the effect of the presence of inosine in RNA by generating an i...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/157259 |