Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons (MNs), and despite progress, there is no effective treatment. A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxicity of M...

Full description

Bibliographic Details
Main Authors: Martínez, Pablo, Silva, Mónica, Abarzúa, Sebastián, Tevy, María F., Jaimovich, Enrique, Constantine-Paton, Martha, Bustos, Fernando J., van Zundert, Brigitte
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:English
Published: BioMed Central 2024
Online Access:https://hdl.handle.net/1721.1/157459

Internet

https://hdl.handle.net/1721.1/157459

Similar Items