A regulatory role for repeated decoy transcription factor binding sites in target gene expression

Tandem repeats of DNA that contain transcription factor (TF) binding sites could serve as decoys, competitively binding to TFs and affecting target gene expression. Using a synthetic system in budding yeast, we demonstrate that repeated decoy sites inhibit gene expression by sequestering a transcrip...

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Bibliographic Details
Main Authors: Lee, Tek‐Hyung, Maheshri, Narendra
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Nature Publishing Group UK 2024
Online Access:https://hdl.handle.net/1721.1/157538