Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering
Ribonuclease (RNase) 1 is a human protein with a remarkable ability to indiscriminately hydrolyze RNA. RNase 1 and its bovine homologue RNase A exhibit ubiquitous expression across tissues, a catalytic efficiency within the diffusion-limited regime, and minimal substrate sequence requirements. RNase...
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/157812 https://orcid.org/0000-0002-2281-7594 |