Site-specific chemical and topological modifications to augment mRNA therapeutic potential
Synthetic mRNA has emerged as a promising therapeutic platform for the treatment of a wide variety of diseases. Despite clinical demonstrations of mRNA for SARS-CoV-2 vaccines, mRNAs remain limited in application by their susceptibility to nucleases and overall short expression lifetime in vivo. We...
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| Format: | Thesis |
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Massachusetts Institute of Technology
2024
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| Online Access: | https://hdl.handle.net/1721.1/157875 |