Stabilization of Therapeutic Proteins

We present results of molecular simulations, quantum mechanical calculations, and experimental data aimed towards the rational design of solvent formulations. In particular, we have found that the rate limitation of oxidation of methionine groups is determined by the breaking of O-O bonds in hydroge...

Full description

Bibliographic Details
Main Authors: Chu, Jhih-Wei, Yin, Jin, Mazyar, Oleg, Goh, Lin-Tang, Yap, Miranda G.S., Wang, Daniel I.C., Trout, Bernhardt L.
Format: Article
Language:en_US
Published: 2003
Subjects:
Online Access:http://hdl.handle.net/1721.1/3794