On the Oxidation of Methionine Residues during the Storage of Protein Pharmaceuticals in an Aqueous Formulation
This study addresses the fundamentals of an important degradation pathway of storing protein pharmaceuticals in an aqueous formulation, oxidation of methionine residues by peroxides. First, a mechanism by which methionine residues are oxidized is identified via ab initio calculations. The major diff...
| Главные авторы: | , , , |
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| Формат: | Статья |
| Язык: | en_US |
| Опубликовано: |
2003
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| Предметы: | |
| Online-ссылка: | http://hdl.handle.net/1721.1/3940 |