Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice

Spontaneous generation of prion infectivity in fatal familial insomnia knock-in mice

A crucial tenet of the prion hypothesis is that misfolding of the prion protein (PrP) induced by mutations associated with familial prion disease is, in an otherwise normal mammalian brain, sufficient to generate the infectious agent. Yet this has never been demonstrated. We engineered knockin mice...

Full description

Bibliographic Details
Main Authors: Faas, Henryk, Watson, Nicki, Borkowski, Andrew W., Jasanoff, Alan Pradip, King, Oliver D., Steele, Andrew D., Lindquist, Susan, Jackson, Walker S.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier Inc. 2009
Online Access:http://hdl.handle.net/1721.1/49488
https://orcid.org/0000-0002-2834-6359
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/49488
https://orcid.org/0000-0002-2834-6359
https://orcid.org/0000-0003-1307-882X

Similar Items