Bifunctional polymeric inhibitors of human influenza A viruses

Bifunctional polymeric inhibitors of human influenza A viruses

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Purpose. New antiviral agents were prepared by attaching derivatives of sialic acid (1) and of the drug zanamivir (2) to poly(isobutylene-alt-maleic anhydride) (poly-(1 + 2)) or by mixing poly-1 and poly-2, followed by assaying them against wild-type and drug-resistant influenza A Wuhan viruses. Me...

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Bibliographic Details
Main Authors: Haldar, Jayanta, Alvarez de Cienfuegos, Luis, Tumpey, Terrence M., Gubareva, Larisa V., Chen, Jianzhu, Klibanov, Alexander M.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Springer Netherlands 2009
Subjects:
drug-resistant mutant
zanamivir
sialic acid
polymeric antiviral agents
Influenza virus
Online Access:http://hdl.handle.net/1721.1/49840
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

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http://hdl.handle.net/1721.1/49840
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

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