Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36
Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryp...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Rockefeller University Press
2010
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| Online Access: | http://hdl.handle.net/1721.1/52003 |
| _version_ | 1826199823753150464 |
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| author | Means, Terry K. Mylonakis, Eleftherios Tampakakis, Emmanouil Colvin, Richard A. Seung, Edward Puckett, Lindsay Tai, Melissa F. Stewart, Cameron R. Pukkila-Worley, Read Hickman, Suzanne E. Moore, Kathryn J. Calderwood, Stephen B. Hacohen, Nir Luster, Andrew D. El Khoury, Joseph |
| author2 | Broad Institute of MIT and Harvard |
| author_facet | Broad Institute of MIT and Harvard Means, Terry K. Mylonakis, Eleftherios Tampakakis, Emmanouil Colvin, Richard A. Seung, Edward Puckett, Lindsay Tai, Melissa F. Stewart, Cameron R. Pukkila-Worley, Read Hickman, Suzanne E. Moore, Kathryn J. Calderwood, Stephen B. Hacohen, Nir Luster, Andrew D. El Khoury, Joseph |
| author_sort | Means, Terry K. |
| collection | MIT |
| description | Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was β-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens. |
| first_indexed | 2024-09-23T11:26:19Z |
| format | Article |
| id | mit-1721.1/52003 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:26:19Z |
| publishDate | 2010 |
| publisher | Rockefeller University Press |
| record_format | dspace |
| spelling | mit-1721.1/520032022-10-01T03:38:57Z Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 Means, Terry K. Mylonakis, Eleftherios Tampakakis, Emmanouil Colvin, Richard A. Seung, Edward Puckett, Lindsay Tai, Melissa F. Stewart, Cameron R. Pukkila-Worley, Read Hickman, Suzanne E. Moore, Kathryn J. Calderwood, Stephen B. Hacohen, Nir Luster, Andrew D. El Khoury, Joseph Broad Institute of MIT and Harvard Means, Terry K. Means, Terry K. Hacohen, Nir Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans. CED-1 and C03F11.1 mediated antimicrobial peptide production and were necessary for nematode survival after C. neoformans infection. SCARF1 and CD36 mediated cytokine production and were required for macrophage binding to C. neoformans, and control of the infection in mice. Binding of these pathogens to SCARF1 and CD36 was β-glucan dependent. Thus, CED-1/SCARF1 and C03F11.3/CD36 are β-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens. 2010-03-03T15:49:07Z 2010-03-03T15:49:07Z 2009-03 2008-09 Article http://purl.org/eprint/type/JournalArticle 0022-1007 http://hdl.handle.net/1721.1/52003 Means, Terry K. et al. “Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.” The Journal of Experimental Medicine 206.3 (2009): 637-653. en_US http://dx.doi.org/10.1084/jem.20082109 Journal of Experimental Medicine Attribution-Noncommercial-Share Alike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Rockefeller University Press Publisher |
| spellingShingle | Means, Terry K. Mylonakis, Eleftherios Tampakakis, Emmanouil Colvin, Richard A. Seung, Edward Puckett, Lindsay Tai, Melissa F. Stewart, Cameron R. Pukkila-Worley, Read Hickman, Suzanne E. Moore, Kathryn J. Calderwood, Stephen B. Hacohen, Nir Luster, Andrew D. El Khoury, Joseph Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 |
| title | Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 |
| title_full | Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 |
| title_fullStr | Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 |
| title_full_unstemmed | Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 |
| title_short | Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 |
| title_sort | evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors scarf1 and cd36 |
| url | http://hdl.handle.net/1721.1/52003 |
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