A multipathway phosphoproteomic signaling network model of idiosyncratic and inflammatory cytokine-induced toxicity in human hepatocytes

Idiosyncratic drug hepatotoxicity is a hepatotoxicity subset that occurs in a very small fraction of human patients, is poorly predicted by standard preclinical models and in clinical trials, and frequently leads to postapproval drug failure. Animal models utilizing bacterial LPS co-administration t...

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Bibliographic Details
Main Authors: Cosgrove, Benjamin D., Alexopoulos, Leonidas G., Saez-Rodriguez, Julio, Griffith, Linda G., Lauffenburger, Douglas A.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Institute of Electrical and Electronics Engineers 2010
Online Access:http://hdl.handle.net/1721.1/52301
https://orcid.org/0000-0002-1801-5548