Dynamic fluctuations of protein-carbohydrate interactions promote aggregation

Dynamic fluctuations of protein-carbohydrate interactions promote aggregation

Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region. We hypothesized that disruption of protein-carbohydrate interactions in...

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Bibliographic Details
Main Authors: Voynov, Vladimir, Chennamsetty, Naresh, Kayser, Veysel, Helk, Bernhard, Forrer, Kurt, Zhang, Heidi, Fritsch, Cornelius, Heine, Holger, Trout, Bernhardt L.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/52397
https://orcid.org/0000-0003-1417-9470

Internet

http://hdl.handle.net/1721.1/52397
https://orcid.org/0000-0003-1417-9470

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