Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy

Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy

The MAPK signal transduction cascade is dysregulated in a majority of human tumors. Here we report that a nanoparticle-mediated targeting of this pathway can optimize cancer chemotherapy. We engineered nanoparticles from a unique hexadentate-polyD,L-lactic acid-co-glycolic acid polymer chemically co...

Full description

Bibliographic Details
Main Authors: Mashelkar, Raghunath Anant, Chimote, Geetanjali, Soni, Shivani, Harfouche, Rania, Basu, Kaushik, Sengupta, Shiladitya
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: United States National Academy of Sciences 2010
Online Access:http://hdl.handle.net/1721.1/52539

Internet

http://hdl.handle.net/1721.1/52539

Similar Items