ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth

ZBED6, a Novel Transcription Factor Derived from a Domesticated DNA Transposon Regulates IGF2 Expression and Muscle Growth

A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold upregulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size of the heart, and fat deposition. Here, we have identified the repressor and fi...

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Bibliographic Details
Main Authors: Andersson, Leif, Hjalm, Goran, Andersson, Goran, Lindblad-Toh, Kerstin, Wadelius, Claes, Kullander, Klas, Zierath, Juleen R., Ponten, Fredrik, De, Sachinandan, Stromberg, Sara, Yan, Jie, Barres, Romain, Lindroth, Anders M., Gnirke, Andreas, Saenz-Vash, Veronica, Wang, Li, Zhang, Xiaolan, Larhammar, Martin, Wallerman, Ola, Jaffe, Jacob D., Jiang, Lin, Markljung, Ellen, Mikkelsen, Tarjei Sigurd, 1978-, Carr, Steven A, Lander, Eric Steven
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/55349
https://orcid.org/0000-0002-7203-4299

Internet

http://hdl.handle.net/1721.1/55349
https://orcid.org/0000-0002-7203-4299

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