Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of a polygl...

Full description

Bibliographic Details
Main Authors: Lindquist, Susan, Steele, Andrew D., Wacker, Jennifer L., Huang, Shao-Yi, Aron, Rebecca, Lotz, Gregor P., Nguyen, QuangVu, Giorgini, Flaviano, Roberson, Erik D., Masliah, Eliezer, Muchowski, Paul J.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Society for Neuroscience 2010
Online Access:http://hdl.handle.net/1721.1/56557
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/56557
https://orcid.org/0000-0003-1307-882X

Similar Items