Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM[subscript 3] Ubiquitin Ligase in Rat Hippocampal Neurons

Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM[subscript 3] Ubiquitin Ligase in Rat Hippocampal Neurons

Changes in neuronal activity modify the structure of dendritic spines and alter the function and protein composition of synapses. Regulated degradation of postsynaptic density (PSD) proteins by the ubiquitin-proteasome system is believed to play an important role in activity-dependent synaptic remod...

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Bibliographic Details
Main Authors: Sheng, Morgan Hwa-Tze, Sung, Clifford C., Brito, Ilana Lauren, Hung, Albert Y.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Public Library of Science 2010
Online Access:http://hdl.handle.net/1721.1/57572

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http://hdl.handle.net/1721.1/57572

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